三位理科宅男，大學時期就是換帖好友，畢業後卻面臨金融風暴而失業，只好隨便找份工作餬口。某天，成為化學系教授的貝德羅（大衛貝爾塔格飾演），打造出一款增強注意力的維生素，卻因為研究經費不足慘遭校方解雇。走投無路之下，貝德羅竟揪兩位好友一起吞了這款維生素，更意外發現這款藥丸不但沒有副作用，還會讓人情緒高亢！於是，他們決定不當乖乖牌，開始走歪路開啟製毒事業，想靠賣藥日進斗金，天天開趴嗨到翻。不過他們萬萬沒想到，原本平凡的生活，就這樣陷入充滿危險的夜世界…。

Maca(MaríaValverde),30yearsoldandclumsybynature,makesthemostoflifeandstrivestobehappy.Maca’stalentiswastedworkingasanassistantforanoppressiveandterrifyingfashioninfluencerandshespendshertimewithguyswithwhomshenevermanagestoestablishanemotionalbond.TogetherwithJimena(ElísabetCasanovas)andAdriana(SusanaAbaitúa),hertwouniqueandlovablefriendswhoarealwaysreadytodowhateverittakestomaketheirproblemsnotseemsobad,MacahasmanagedtomakeMadridacitywhereeverythingispossible.Everythingseemstobegoingwelluntilhe-who-must-not-be-namedcomesbackintoherlife.Leo(AlexGonzález),theloveandbiggestmistakeofherlife,themanwhotoreherheartapart,obliteratedherself-esteemandherfaithinmen,comesbackintoherlifetoturneverythingupsidedown.Macahastriedtoforgethim,butnowshehastoacceptthathehasreturnedandfacetheemotionsshehaslockedawaytodealwiththeunforgettablememoryofwhatcouldhavebeenandneverwas.OldwoundsarereopenedandMacawillhavetobebraveandconfrontherconflicts,fearsandinsecuritiesinordertofinallytakecontrolofherlife.